2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-145577A
    Lafadofensine (D-(-)-Mandelic acid) 99.95%
    Lafadofensine D-(-)-Mandelic acid is the monoamines reuptake inhibitor. Lafadofensine D-(-)-Mandelic acid has sufficient effects after short-term administration.
    Lafadofensine (D-(-)-Mandelic acid)
  • HY-14557S1
    Pimavanserin-d4
    Pimavanserin-d4 (ACP-103-d4) is the deuterium labeled Pimavanserin (HY-14557). Pimavanserin is a selective, brain-penetrant, inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
    Pimavanserin-d4
  • HY-145833A
    sEH/AChE-IN-4 2490589-12-1 98%
    sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively.
    sEH/AChE-IN-4
  • HY-14605BS
    Rasagiline-13C3 mesylate racemic 1216757-55-9 98%
    Rasagiline-13C3 (mesylate racemic) is a 13C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Rasagiline-13C3 mesylate racemic
  • HY-14608AR
    L-Glutamic acid monosodium salt (Standard) 142-47-2 98%
    L-Glutamic acid (monosodium salt) (Standard) is the analytical standard of L-Glutamic acid (monosodium salt). This product is intended for research and analytical applications. L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases.
    L-Glutamic acid monosodium salt (Standard)
  • HY-14608S9
    L-Glutamic acid-15N,d5 98%
    L-Glutamic acid-15N,d5 is the deuterium and 15N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
    L-Glutamic acid-15N,d5
  • HY-146663A
    AChE/BChE-IN-3 hydrochloride 2410992-69-5 98%
    AChE/BChE-IN-3 (BMC-1) hydrochloride is a dual AChE and BChE inhibitor with IC50 values of 6.08 μM and 0.383 μM against electric eel AChE (elAChE) and equine serum BChE (eqBChE), respectively.
    AChE/BChE-IN-3 hydrochloride
  • HY-147059R
    Dieckol (Standard) 88095-77-6
    Buclizine (dihydrochloride) (Standard) is the analytical standard of Buclizine (dihydrochloride). This product is intended for research and analytical applications. Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat and shows anti-tumor activity.
    Dieckol (Standard)
  • HY-147331A
    Oseltamivir acid methyl ester hydrochloride 208720-78-9 98%
    Oseltamivir acid methyl ester hydrochloride is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester hydrochloride is converted to oseltamivir acid by carboxylesterase 1 (CES1).
    Oseltamivir acid methyl ester hydrochloride
  • HY-147720A
    γ-Secretase modulator 11 hydrochloride 2434630-30-3 98%
    γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease.
    γ-Secretase modulator 11 hydrochloride
  • HY-14794AS
    Levomilnacipran-d10 hydrochloride 2747914-23-2 98%
    Levomilnacipran-d10 ((1S,2R)-Milnacipran-d10) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression.
    Levomilnacipran-d10 hydrochloride
  • HY-148708A
    Oleoyl-D-lysine sodium
    Oleoyl-D-lysine sodium is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine sodium reverses neuropathic pain in mice, shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine sodium is safe and effective without respiratory depression.
    Oleoyl-D-lysine sodium
  • HY-148718R
    4-Chloro Trazodone hydrochloride (Standard) 1263278-77-8
    4-Chloro Trazodone (hydrochloride) (Standard) is the analytical standard of 4-Chloro Trazodone (hydrochloride). This product is intended for research and analytical applications. 4-Chloro Trazodone hydrochloride is an isomer of Trazodone hydrochloride (HY-B0478). Trazodone hydrochloride is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.
    4-Chloro Trazodone hydrochloride (Standard)
  • HY-148828A
    LSP-GR3 sodium
    LSP-GR3 sodium is a novel chemically-modified RNA oligonucleotides, called splice modulating oligomers (SMOs), which potently and specifically modulate GluR alternative splicing to GluR3-flip expression throughout the CNS.
    LSP-GR3 sodium
  • HY-148828C
    LSP-GR3 sodium scrambled negative control 98%
    LSP-GR3 sodium scrambled negative control is the sequence scrambled negative control of LSP-GR3 sodium.
    LSP-GR3 sodium scrambled negative control
  • HY-148828D
    FAM labled LSP-GR3 sodium 98%
    FAM labled LSP-GR3 sodiumis a FAM labled LSP-GR3 sodium.
    FAM labled LSP-GR3 sodium
  • HY-148828E
    Cy3 labled LSP-GR3 sodium 98%
    Cy3 labled LSP-GR3 sodium is a Cy3 labled LSP-GR3 sodium.
    Cy3 labled LSP-GR3 sodium
  • HY-149804A
    S1R agonist 2 hydrochloride ≥98.0%
    S1R agonist 2 (Compound 8b) hydrochloride is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity.
    S1R agonist 2 hydrochloride
  • HY-149854A
    AB21 oxalate 98%
    AB21 oxalate is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 oxalate has the effect of reducing mechanical hypersensitivity.
    AB21 oxalate
  • HY-15122AR
    Sinomenine hydrochloride (Standard) 6080-33-7 98%
    Sinomenine hydrochloride (Standard) is the analytical standard of Sinomenine hydrochloride. This product is intended for research and analytical applications. Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor.
    Sinomenine hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity